Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification.
نویسندگان
چکیده
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.
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عنوان ژورنال:
- Chemical communications
دوره 25 شماره
صفحات -
تاریخ انتشار 2007